N-{2-methyl-5-[(6-phenylpyrimidin-4-yl)amino]phenyl}methanesulfonamide

N-{2-methyl-5-[(6-phenylpyrimidin-4-yl)amino]phenyl}methanesulfonamide is a synthetic small molecule belonging to the phenylpyrimidine class. It is characterized by a sulfonamide group and a pyrimidine ring substituted with a phenyl group. The compound has been identified as an inhibitor of β-secretase 1 (BACE1), an enzyme involved in the cleavage of amyloid precursor protein, which is relevant to Alzheimer's disease pathology. Its primary research interest lies in its potential as an anti-Alzheimer's agent, though it also exhibits antimicrobial and anti-inflammatory properties[9]. There are no known approved therapeutic uses or marketed formulations for this compound.

Other names

N-[2-methyl-5-[(6-phenylpyrimidin-4-yl)amino]phenyl]methanesulfonamideN-(2-methyl-5-(6-phenylpyrimidin-4-ylamino)phenyl)methanesulfonamideβ-secretase 1 inhibitor (BACE1_HUMAN)CHEMBL469117CHEMBL-469117CHEMBL 469117DB07175DB-07175DB 07175